McClaren will try again with a 4-3-3 formation used in last November's 1-1 friendly draw in the Netherlands, with Crouch flanked up front by Shaun Wright-Phillips and Kieron Dyer.
Wright-Phillips gets his chance at Old Trafford after McClaren said Aaron Lennon had been ruled out by a stomach bug that had dogged the winger for several days.
Holding player Michael Carrick will anchor a more familiar three-man field, with Frank Lampard to his left and Steven Gerrard on the right.
Bigger changes are in store at the back, largely due to injury absences, with Phil Neville stepping in after England lost both their left-backs, Ashley Cole and Wayne Bridge.
Captain John Terry's long-term injury absence means he will be rested and his place alongside Rio Ferdinand handed to Jonathan Woodgate, with Gary Neville at right back.
McClaren dropped first-choice goalkeeper Paul Robinson in order to give Ben Foster his England debut and a taste of international football.
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